Disseminated histoplasmosis - comment 1

Disseminated CNS histoplasmosis.

Although an estimated 40 million Americans have been infected with Histoplasma capsulatum [1], CNS involvement is rare except in the disseminated form. Lesions of the CNS have been reported to occur in nearly one fourth of the documented cases of disseminated histoplasmosis [2], but only in a few cases has the infection solely involved the CNS [3, 4]. This article details the cranial CT and spi...

Subdural Empyema in Disseminated Histoplasmosis

A 34-year-old man presented with two episodes of generalized tonic–clonic seizures and fever for 1 day. Two months back, he was admitted with high grade fever, productive cough, cervical lymphadenopathy, left lower lobe consolidation, and multiple skin abscesses. The pus from the abscess was drained and the abscess wall histopathology revealed intracellular oval shaped fungal organisms with nar...

Disseminated histoplasmosis and its treatment.

Disseminated histoplasmosis associated with acquired hemophagocytic lymphohistiocytosis

Hemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening clinical syndrome caused by uncontrolled activation of lymphocytes and histiocytes resulting in high levels of cytokines. Acquired HLH occurs in autoimmune, inflammatory, infectious, and immunosuppressive disorders. Prompt identification and treatment of an underlying triggering cause improves clinical outcome.

Extrapulmonary tuberculosis masking disseminated histoplasmosis in AIDS.

Case presentation (Dr L Greene and Dr A L Pozniak) A 32 year old black African man was admitted from our emergency clinic complaining of right sided abdominal pain which was dull in nature with colicky exacerbations that had been present for 6 weeks. The pain had increased in severity over the preceding 3 days. The patient also reported watery diarrhoea and weight loss of 7 kg over the same per...